Clinical relevance of genetic variants in juvenile stroke patients: A plea for a precise classification.

Annals of NeurologyVolume 94, Issue 3 p. 608-608 Letter/Reply Clinical Relevance of Genetic Variants in Juvenile Stroke Patients: A Plea for a Precise Classification Johanna Härtl MD, Corresponding Author Johanna Härtl MD [email protected] orcid.org/0000-0002-2672-0175 School of Medicine, Klinikum rechts der Isar, Department of Neurology, Technical University of Munich, Munich, Germany Address correspondence to Dr Härtl, School of Medicine, Klinikum rechts der Isar, Department of Neurology, Technical University of Munich, Ismaninger Str 22, 81675 München, Germany. E-mail: [email protected]Search for more papers by this authorTobias B. Haack MD, Tobias B. Haack MD Eberhard Karls University, School of Medicine, Universitätsklinikum Tübingen, Institute of Medical Genetics and Applied Genomics, Tübingen, GermanySearch for more papers by this authorIsabell Cordts MD, Isabell Cordts MD School of Medicine, Klinikum rechts der Isar, Department of Neurology, Technical University of Munich, Munich, GermanySearch for more papers by this authorMarcus Deschauer MD, Marcus Deschauer MD School of Medicine, Klinikum rechts der Isar, Department of Neurology, Technical University of Munich, Munich, GermanySearch for more papers by this author Johanna Härtl MD, Corresponding Author Johanna Härtl MD [email protected] orcid.org/0000-0002-2672-0175 School of Medicine, Klinikum rechts der Isar, Department of Neurology, Technical University of Munich, Munich, Germany Address correspondence to Dr Härtl, School of Medicine, Klinikum rechts der Isar, Department of Neurology, Technical University of Munich, Ismaninger Str 22, 81675 München, Germany. E-mail: [email protected]Search for more papers by this authorTobias B. Haack MD, Tobias B. Haack MD Eberhard Karls University, School of Medicine, Universitätsklinikum Tübingen, Institute of Medical Genetics and Applied Genomics, Tübingen, GermanySearch for more papers by this authorIsabell Cordts MD, Isabell Cordts MD School of Medicine, Klinikum rechts der Isar, Department of Neurology, Technical University of Munich, Munich, GermanySearch for more papers by this authorMarcus Deschauer MD, Marcus Deschauer MD School of Medicine, Klinikum rechts der Isar, Department of Neurology, Technical University of Munich, Munich, GermanySearch for more papers by this author First published: 19 July 2023 https://doi.org/10.1002/ana.26742Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Park H-K, Lee K-J, Park J-M, et al. Prevalence of mutations in Mendelian stroke genes in early onset stroke patients. Ann Neurol 2023; 93: 768–782. https://doi.org/10.1002/ana.26575. 2De Vilder EYG, Cardoen S, Hosen MJ, et al. Pathogenic variants in the ABCC6 gene are associated with an increased risk for ischemic stroke. Brain Pathol 2018; 28: 822–831. https://doi.org/10.1111/bpa.12620. 3Bersano A, Khan N, Fuentes B, et al. European stroke organisation (ESO) guidelines on Moyamoya angiopathy: endorsed by vascular European reference network (VASCERN). Eur Stroke J 2023; 8: 55–84. https://doi.org/10.1177/23969873221144089. 4Richards S, Aziz N, Bale S, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 2015; 17: 405–423. https://doi.org/10.1038/gim.2015.30. 5Härtl J, Hartberger J, Wunderlich S, et al. Exome-based gene panel analysis in a cohort of acute juvenile ischemic stroke patients:relevance of NOTCH3 and GLA variants. J Neurol 2022; 270: 1501–1511. https://doi.org/10.1007/s00415-022-11401-7. Volume94, Issue3September 2023Pages 608-608 ReferencesRelatedInformation