Using an experiment among clinical experts to determine the cost and clinical impact of rapid whole exome sequencing in acute pediatric settings.

Nattiya Kapol,Wuttichart Kamolvisit,Lalida Kongkiattikul, Evan Huang-Ku, Namfon Sribundit,Surasit Lochid-Amnuay,Nathapol Samprasit, Thamonwan Dulsamphan, Parntip Juntama,Chotika Suwanpanich, Ponghathai Boonsimma,Vorasuk Shotelersuk,Yot Teerawattananon

Frontiers in pediatrics（2023）

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摘要

In acute pediatric settings, rWES offered clinical benefits at the average cost of 60,000-70,000 THB. Whether this test is cost-effective warrants further investigations. Several challenges, including cost and ethical concerns for assessing high-cost technology for rare diseases in resource-limited settings, were potentially overcome by our study design using expert elicitation methods.

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关键词

rapid whole-exome sequencing, cost-effectiveness, next-generation sequencing, low- and middle-income countries, acute pediatrics

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