Euphopias G- J, macrocyclic diterpenes with anti-zika virus activity from Euphorbia helioscopia L
Fitoterapia(2023)
Abstract
Four new diterpenoids (1-4) and sixteen known diterpenoids (5-20) were purified from the whole plant of Euphorbia helioscopia L. Compounds 1 and 2 were rhamofolane diterpenoids with a 5/7/6 tricyclic systems, compound 3 was a lathyranes diterpenoid, and compound 4 was a jathophanes diterpenoid. The isolated compounds were tested for their cytotoxicity and anti-Zika virus properties, and compounds 9 and 15 showed low cytotoxicity and strong anti-Zika virus properties with EC50 2.63 and 5.94 & mu;M, respectively. Further, the inhibitory effects of compounds on protein levels were determined using Western blotting and immunofluorescence assays.
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Key words
Diterpenoids,Anti-Zika virus activity,Cytotoxicity,Euphorbia helioscopiaL.
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