Formal Synthesis of Ecteinascidin 743 from N -Cbz-l-tyrosine.

The Journal of organic chemistry(2023)

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摘要
A formal total synthesis of ecteinascidin 743 and lurbinectedin is achieved. Key features involve a Pictet-Spengler cyclization coupling of the tetrahydroisoquinoline and phenylalaninol moieties prepared by a common route with high yield and selectivity, a Parikh-Doering oxidation with good chemoselectivity and functionality tolerance, and a light-mediated A-ring elaboration of pentacyclic methoxyquinone substrates. By the approach, the known advanced intermediate (4-step conversion to Et-743) can be obtained conveniently in 21 total steps from -Cbz-l-tyrosine.
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ecteinascidin,formal synthesis
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