Fibrinolytic and antibiotic treatment of prosthetic vascular graft infections in a novel rat model.

PloS one(2023)

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摘要
We developed the first functional model of an arterial prosthetic vascular graft infection in rats. Antibiotic combination therapy with vancomycin and rifampicin was superior to vancomycin monotherapy, and the addition of tPA did not significantly reduce bacterial load, nor significantly increase cure rate.
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关键词
prosthetic vascular graft infections,antibiotic treatment
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