Salidroside alleviates UVB-induced skin damage by inhibiting keratinocytes pyroptosis via the AQP3/ROS/GSDMD-N signaling pathway

Manxue Mei,Ruhang Cai,Qihua Yu, Renkui Tian,Wei Zhu,Jianping Song,Dinghong Wu

Journal of Functional Foods（2023）

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摘要

•Salidroside attenuates UVB-induced injury both in vivo and in vitro.•Salidroside decreases the AQP3 overexpression caused by UVB irradiation.•Salidroside alleviates UVB-induced oxidative events and pyroptosis.•Salidroside suppresses pyroptosis and oxidative stress via down-regulation AQP3/ROS/GSDMD-N signaling pathway.

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关键词

Salidroside, UVB, AQP3, Pyroptosis, Keratinocytes, Oxidative stress

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