Novel Nutraceutical (silymarin, yeast β-glucan, prebiotics, and minerals) shifts gut microbiota and restores large intestine histology of diet-induced metabolic syndrome mice

•The Novel Nutraceutical supplement recovers gut epithelium morpho-histology.•The supplementation increases gut microbiota diversity in high-fat-diet dysbiosis.•Firmicutes/Bacteroidetes ratio increased by the Novel Nutraceutical supplement.•The supplementation restores gut epithelium without Akkermansia genus interaction.