Jian-Pi-Yin decoction attenuates lactose-induced chronic diarrhea in rats by regulating GLP-1 and reducing NHE3 ubiquitination and phosphorylation

Jin-xin Ma,Ting Chen,Hong Xue,Min Zhang,Zhong-yu Li,Xuan Li,Yi-tian Wang,Nan Kang,Feng-yun Wang,Xu-dong Tang

Heliyon（2023）

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摘要

In this study, we explored the mechanism of intestinal GLP-1 activation of cAMP/PKA signaling pathway from multiple dimensions, and increased its expression by reducing phosphorylation and ubiquitination of NHE3, thereby treating chronic diarrhea associated with lactose intolerance.

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关键词

chronic diarrhea,nhe3 ubiquitination,jian-pi-yin,lactose-induced

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