IL-7 receptor expression is frequent in T-cell acute lymphoblastic leukemia and predicts sensitivity to JAK inhibition

Lucien Courtois,Aurélie Cabannes-Hamy,Rathana Kim,Marine Delecourt,Antoine Pinton,Guillaume Charbonnier,Mélanie Feroul,Charlotte Smith,Giulia Tueur,Cécile Pivert,Estelle Balducci,Mathieu Simonin,Laure Hélène Angel,Salvatore Spicuglia,Nicolas Boissel,Guillaume P. Andrieu,Vahid Asnafi,Philippe Rousselot,Ludovic Lhermitte

Blood（2023）

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摘要

•IL-7R/CD127 expression is frequent in T-ALL (∼70%) and aberrantly diverges from normal thymocytic development.•IL-7R/CD127 expression predicts sensitivity to JAK inhibition in T-ALL and synergism with BCL2 inhibition.

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