Development of a biocompatible green drug release system using salidroside-TiO2-doped chitosan oligosaccharide molecularly imprinted polymers

Zijie Liu,Xingbin Ma,Shuyu Li,Jiajie Qiu,Siyu Liu,Zhifeng Huang,Hongling Lin,A.M. Abd El-Aty

Arabian Journal of Chemistry（2023）

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Abstract

•In this study, salidroside (SD) was used as a template molecule to synthesize a molecularly imprinted polymer (MIP) using TiO2-doped chitosan oligosaccharides as the functional monomer.•The SDT-MIPs had good adsorption properties for salidroside. The SDT-MIPs were able to reach the maximum concentration of the drug after 4 h in simulated gastric fluid.•The SDT-MIPs are biocompatible and have potential for use in drug delivery applications.

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Key words

Surface molecularly, imprinted polymer, Novel functional monomer, Diethylene glycol, Sustained release, Salidroside, dimethacrylate

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