Recent Progress in Asymmetric Domino Intramolecular Cyclization/Cascade Reactions of Substituted Olefins.

Domino cyclization/coupling strategy is one of the most effective methods to produce cyclized and multi-functionalized compounds from olefins, which has attracted huge attentions from chemists and biochemists especially for its considerable potential of enantiocontrol. Nowadays, more and more researches are developed to achieve difunctionalization of substituted olefins through the asymmetric domino intramolecular cyclization/cascade reactions, which is still the elegant choice to accomplish several synthetic ideas such as complex natural products and drugs. This review surveys the recent advances in this field through reaction type classification. It might serve as useful knowledge desktop to the community and accelerates their researches.