SENP2-mediated SERCA2a DeSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury.

Yuanyuan Luo,Shuaishuai Zhou,Tao Xu,Wanling Wu,Pingping Shang,Shuai Wang,Defeng Pan,Dongye Li

Chinese medical journal（2023）

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摘要

I/RI activated Senp1 and Senp2 protein expression, which promoted Serca2a-deSUMOylation, while inhibition of Senp2 expression reversed Serca2a-SUMOylation and improved cardiac function.

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关键词

myocardial ischemia/reperfusion,calcium overload,cardiomyocytes

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