RNA-binding Protein QKI Inhibits Osteogenic Differentiation Via Suppressing Wnt Pathway.

Zhao Yan,Banjun Ruan,Shan Wang,Tianshu Du,Xiaolong Shao,Guo Chen, Li Wang,Dongsheng Zhai,Shu Zhu,Zifan Lu,Xiaorui Cao

Archives of medical research（2023）

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摘要

QKI suppressed BMSCs osteogenic differentiation by downregulating the expressions of Wnt5b, Fzd7, Dvl3 and β-catenin. Loss of QKI in BMSCs transplantation may provide a new strategy for the treatment of orthopedic diseases such as osteoporosis.

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关键词

BMSCs,BMSCs transplantation,Osteogenic differentiation,QKI,Wnt pathway

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