A new art to treating osteoarthritis pain?

Osteoarthritis (OA) pain involves peripheral and central neural pathways, as well as interactions between multiple cell types and soluble mediators. 1 Pattison L.A. Krock E. Svensson C.I. Smith E.St.J. Cell–cell interactions in joint pain: rheumatoid arthritis and osteoarthritis. Pain. 2021; 162: 714-717https://doi.org/10.1097/j.pain.0000000000002174 Crossref Scopus (5) Google Scholar Although therapeutic targeting of peripheral OA pain pathways might prove simpler and be associated with fewer side effects, the complexity of OA pain means that it will likely be the case that what works for one patient will be inefficacious for another. Consequently, it is important to further our understanding of OA pain mechanisms to develop new treatments and thus expand the clinician’s therapeutic arsenal.