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Phosphorylation of αB-Crystallin Involves Interleukin-1β-Mediated Intracellular Retention in Retinal Müller Cells: A New Mechanism Underlying Fibrovascular Membrane Formation.

Taku Yamamoto,Satoru Kase,Akihiro Shinkai,Miyuki Murata,Kasumi Kikuchi,Di Wu,Yasushi Kageyama,Masami Shinohara,Tomohiko Sasase,Susumu Ishida

Investigative ophthalmology & visual science（2023）

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Abstract
The Ser59 phosphorylation of αB-crystallin was modulated by IL-1β in Müller cells under diabetic mimicking inflammatory conditions, suggesting that αB-crystallin contributes to the pathogenesis of PDR through an anti-apoptotic effect.
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Key words
retinal müller cells,phosphorylation,intracellular retention,b-crystallin
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