Male Obesity Is Associated with Meningiomas: A U.S. Population-Based Study with Validation in an Institutional Cohort

Background: Women have a higher prevalence of meningiomas, and meningiomas express estrogen and progesterone receptors, suggesting a hormonal influence on tumorigenesis. Obesity in men is associated with increased circulating estrogen via an increase in aromatase-expressing adipocytes. We hypothesized obese men were more likely to have meningiomas.