Palladium-catalyzed regioselective arylation of 7-hydroxyflavone with diaryliodonium salts

A palladium-catalyzed regioselective arylation at the C6 position of 7-hydroxyflavone protocol was dis-closed for the first time. The reaction occurs in carbamate directing group directed C-H activation man-ner. The key to this high regioselectivity is the appropriate choice of carbamates as protecting/directing groups and H3PO4 additive in the presence of Pd (TFA)2 catalyst. Additionally, the procedure provided an expedient approach for the preparation of 6-arylflavone derivatives.& COPY; 2023 Elsevier Ltd. All rights reserved.