Total synthesis of (±)-applanatumol B
Tetrahedron Letters（2023）
Abstract
Total synthesis of (±)-applanatumol B has been achieved in in 8 steps from known compound 8 in 5.0% overall yield. The key step features an acid induced cyclization to construct 5/5/6 tricyclic skeleton. Incorporation of dimethyl malonate into the pentane ring simplifies the synthesis by reducing stereocenters to two.
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Key words
Total synthesis,Applanatumol B
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