Palladium-catalyzed cross-coupling of terminal alkynes with di-tert-butyl dicarbonate: Facile access to functionalized alkynoate esters

An efficient palladium-catalyzed alkoxycarbonylation of terminal alkynes was developed using di-tert-butyl dicarbonate as the ester source. This protocol proceeded under mild conditions and exhibited a board substrate scope. The successful application of gram-scale synthesis and product derivatization further confirmed the synthetic utility of this method. Thus it provides a powerful route to the synthesis of diverse functionalized alkynoate esters.