Humoral immune responses to inactivated COVID-19 vaccine up to 1 year in children with chronic hepatitis B infection.

Yingzhi Zhou,Zhiwei Chen, Yi He,Xiaorong Peng,Yunan Chang,Aoxue Tan,Hu Li,Dachuan Cai,Peng Hu,Min Chen,Mingli Peng,Hongmei Xu,Hong Ren

Frontiers in cellular and infection microbiology（2023）

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摘要

Inactivated vaccination could elicit more robust and durable antibody responses to the wild-type SARS-CoV-2 strain in CHB children than in CHB adults but showed inferior responses to Omicron subvariants (especially to the BA.5 strain). Hence, new Omicron-related or all-in-one vaccines are needed immediately for CHB children.

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humoral immune responses,vaccine

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