White matter microstructural perturbations after total sleep deprivation in depression.

Brandon Taraku,Artemis Zavaliangos-Petropulu,Joana R Loureiro,Noor B Al-Sharif,Antoni Kubicki,Shantanu H Joshi,Roger P Woods,Randall Espinoza,Katherine L Narr,Ashish K Sahib

Frontiers in psychiatry（2023）

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摘要

Total sleep deprivation leads to rapid microstructural changes in WM pathways in patients with depression that are distinct from WM changes associated with TSD observed in HCs. WM tracts including the superior corona radiata and posterior thalamic radiation could be potential biomarkers of the rapid therapeutic effects of TSD. Changes in superior corona radiata FA, in particular, may relate to improvements in maladaptive rumination.

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关键词

sleep deprivation, white matter, depression, diffusion imaging, rumination

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