SMARCB1/INI1 loss in skull base conventional chordomas: a clinicopathological and molecular analysis.
Frontiers in oncology(2023)
Abstract
Partial loss of SMARCB1/INI1, secondary to heterozygous deletion and/or copy number gain of SMARCB1, is not peculiar of aggressive forms, but can be identified by immunohistochemistry in a significant portion of conventional skull base chordomas, including the chondroid subtype. The variable protein expression does not appear to correlate with clinicopathological parameters, nor survival outcomes, but still, it could have therapeutic implications.
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Key words
conventional chordomas,smarcb1/ini1 loss,skull base
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