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APOE ε4 allele, along with G206D - PSEN1 mutation, alters mitochondrial networks and their degradation in Alzheimer's disease.

Irene Costa-Laparra,Elena Juárez-Escoto,Carlos Vicario,Rosario Moratalla,Patricia García-Sanz

Frontiers in aging neuroscience（2023）

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Abstract
The findings suggest that all these modifications could eventually contribute to the neuronal degeneration that underlies the pathogenesis of Alzheimer's disease. Further research in this area may help to develop targeted therapies for the treatment of Alzheimer's disease.
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Key words
apoe ε4 allele,alzheimers,mitochondrial networks,d-psen
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