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The effects of coagulation factors and their inhibitors on proliferation and migration in colorectal cancer.

Peter Adam Rees,John Castle,Hamish William Clouston,Rebecca Lamb, Urvashi Singh,Sarah Elizabeth Duff,Cliona Clare Kirwan

Cancer medicine（2023）

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Abstract
Thrombin, FXa and TF all increase migration in CRC in vitro. Thrombin induced increase in proliferation is abrogated by dabigatran. Dabigatran may have potential as an anti-cancer therapy in CRC.
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Key words
coagulation factors, colorectal cancer, migration, proliferation
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