A photoactive lysosome targeting Ru^II complex downregulates stemness genes in oral squamous cell carcinoma

Souryadip Roy,Paromita Mitra,Sourav Acharya,Shantanu Saha Roy,Moumita Maji,Niladri Modak,Nirmalya Ghosh,Moulinath Acharya,Sandeep Singh, A. Mukherjee,Shilpendu Ghosh

Inorganic chemistry frontiers（2022）

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摘要

Morphocumin coordinated Ru II – p -cymene complex acts as a type-I photosensitizer to inhibit growth of CSC enriched 3D-spheroids of oral squamous carcinoma downregulating stemness genes (cMYC, SOX2, OCT4) with no systemic toxicity to zebrafish embryos in the dark.

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photoactive lysosome,oral squamous cell carcinoma,genes

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A photoactive lysosome targeting RuII complex downregulates stemness genes in oral squamous cell carcinoma

A photoactive lysosome targeting Ru^II complex downregulates stemness genes in oral squamous cell carcinoma