Pd18-02 describing patterns of familial cancer risk in subfertile men using population pedigree data

You have accessJournal of UrologyCME1 Apr 2023PD18-02 DESCRIBING PATTERNS OF FAMILIAL CANCER RISK IN SUBFERTILE MEN USING POPULATION PEDIGREE DATA Joemy Ramsay, Joshua Horns, Benjamin Emery, Kenneth Aston, and James Hotaling Joemy RamsayJoemy Ramsay More articles by this author , Joshua HornsJoshua Horns More articles by this author , Benjamin EmeryBenjamin Emery More articles by this author , Kenneth AstonKenneth Aston More articles by this author , and James HotalingJames Hotaling More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003273.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Subfertile men and their relatives show increased risk for certain cancers including testis, pediatric leukemia/lymphoma, thyroid, and prostate. We assessed risk for multiple cancers simultaneously to identify distinct familial multicancer patterns (FMPs) in azoospermic and oligozoospermic men. METHODS: We identified azoospermic (N=809) and oligozoospermic (N=669) men in the Subfertility, Health and Assisted Reproduction (SHARE) cohort and their family members out to third-degree relatives (azoo: N=27,148; oligo: N=23,626). Cancer cases were identified using the Utah Cancer Registry, a population-based SEER registry with statewide cancer records from 1966. Families with ≥10 individuals who lived in Utah for ≥1 year 1966-2017 were included in the analysis (azoo: N=426 families, 21,361 individuals; oligo: N=360 families, 18,818 individuals). The famcluster R package was used to cluster families on familial standardized incidence ratios (FSIRs). FSIRs were calculated across 34 cancer types and a weighted Gower distance with k-mediods clustering (k=2:20) was used to identify FMPs. k was selected using silhouette plots and consensus clusters with 1,000 bootstrap replicates. FMPs were assessed separately for azoospermia and oligospermia families. RESULTS: 13 FMPs were identified in azoospermia families and 12 FMPs in oligozoospermia families. Distinct overall patterns of familial cancer were observed between azoospermia and oligozoospermia families (Table 1). 12 out of 13 FMPs (36% of families) showed significantly increased risk for ≥1 cancer in azoospermia families and 11 out of 12 FMPs (40% of the families) showed significantly increased cancer risk in oligozoospermia families (Figure 1). CONCLUSIONS: This analysis described FMPs for subfertile men, with 36-40% of families showing elevated risk for ≥1 cancer. FMPs were unique between azoospermia and oligozoospermia families, suggesting heterogeneity in familial cancer risk by both type of subfertility and within subfertility type. Source of Funding: GEMS: Genomic approach to connecting Elevated germline Mutation rates with male infertility and Somatic health NICHD: R01 HD106112 © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e502 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Joemy Ramsay More articles by this author Joshua Horns More articles by this author Benjamin Emery More articles by this author Kenneth Aston More articles by this author James Hotaling More articles by this author Expand All Advertisement PDF downloadLoading ...