Mp32-08 aortic calcification burden is associated with an increased risk of acute kidney injury in patients who undergoing radical cystectomy: a multi-institutional retrospective cohort study

You have accessJournal of UrologyCME1 Apr 2023MP32-08 AORTIC CALCIFICATION BURDEN IS ASSOCIATED WITH AN INCREASED RISK OF ACUTE KIDNEY INJURY IN PATIENTS WHO UNDERGOING RADICAL CYSTECTOMY: A MULTI-INSTITUTIONAL RETROSPECTIVE COHORT STUDY Naoki Fujita, Masaki Momota, Hirotaka Horiguchi, Shingo Hatakeyama, Hiroyuki Ito, Takahiro Yoneyam, Yasuhiro Hashimoto, Shoji Nishimura, Kazuaki Yoshikawa, and Chikara Ohyama Naoki FujitaNaoki Fujita More articles by this author , Masaki MomotaMasaki Momota More articles by this author , Hirotaka HoriguchiHirotaka Horiguchi More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Hiroyuki ItoHiroyuki Ito More articles by this author , Takahiro YoneyamTakahiro Yoneyam More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , Shoji NishimuraShoji Nishimura More articles by this author , Kazuaki YoshikawaKazuaki Yoshikawa More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003265.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Although acute kidney injury (AKI) is one of the frequent complications in patients undergoing radical cystectomy (RC), its risk factors remain unclear. As arterial degradation is suggested to be a risk factor for renal impairment, we hypothesized that preexisting aortic calcification may play a crucial role in AKI development. METHODS: This multi-institutional retrospective cohort study included 616 patients with muscle invasive bladder cancer who underwent RC between September 1998 and April 2022. Aortic calcification burden was quantified with aortic calcification index using preoperative computed tomography scan (ACI, %) (Fig. A). Patients were divided into two groups: lower ACI (ACI <25%) and higher ACI groups (ACI ≥25%). AKI was defined according to the KDIGO criteria. Multivariable logistic regression analysis was performed to evaluate the association between aortic calcification burden and the risk of AKI. RESULTS: Of 616 patients, 248 (40%) were classified as the higher ACI group and 335 (54%) developed to AKI (any stage). Rate of AKI development in the higher ACI group was significantly higher than that of the lower ACI group (Fig. B; p<0.001). ACI in patients who developed AKI was significantly higher than that in patients who did not (Fig. C; p<0.001). In univariable analyses, age, performance status, body mass index, hypertension, cardiovascular disease, renal function, neobladder reconstruction, and ACI were associated with AKI development (Table 1). After adjustment for these confounding variables, ACI was selected as a significant independent risk factor for AKI development (Table 2; odds ratio 1.534, p=0.023). CONCLUSIONS: High aortic calcification burden is a risk factor for AKI in patients who undergoing RC. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e443 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Naoki Fujita More articles by this author Masaki Momota More articles by this author Hirotaka Horiguchi More articles by this author Shingo Hatakeyama More articles by this author Hiroyuki Ito More articles by this author Takahiro Yoneyam More articles by this author Yasuhiro Hashimoto More articles by this author Shoji Nishimura More articles by this author Kazuaki Yoshikawa More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement PDF downloadLoading ...