Mp58-01 do open and minimally invasive techniques affect prognosis and survival outcomes in patients undergoing curative surgery for non-metastatic papillary renal cell carcinoma? comparative analysis of a matched-pair cohort from a multi-institutional database

You have accessJournal of UrologyCME1 Apr 2023MP58-01 DO OPEN AND MINIMALLY INVASIVE TECHNIQUES AFFECT PROGNOSIS AND SURVIVAL OUTCOMES IN PATIENTS UNDERGOING CURATIVE SURGERY FOR NON-METASTATIC PAPILLARY RENAL CELL CARCINOMA? COMPARATIVE ANALYSIS OF A MATCHED-PAIR COHORT FROM A MULTI-INSTITUTIONAL DATABASE Selcuk Erdem, Riccardo Bertolo, Riccardo Campi, Umberto Capitanio, Daniele Amparore, Umberto Anceschi, Maria Carme Mir, Eduard Roussel, Nicola Pavan, Umberto Carbonara, Onder Kara, Tobias Klatte, Michele Marchioni, Angela Pecoraro, Stijn Muselaers, Laura Marandino, Pietro Diana, Leonardo Borregales, Enes Degirmenci, Resat Aydin, Giacomo Rebez, Giuseppe Simone, Andrea Minervini, Sergio Serni, and Faruk Ozcan Selcuk ErdemSelcuk Erdem More articles by this author , Riccardo BertoloRiccardo Bertolo More articles by this author , Riccardo CampiRiccardo Campi More articles by this author , Umberto CapitanioUmberto Capitanio More articles by this author , Daniele AmparoreDaniele Amparore More articles by this author , Umberto AnceschiUmberto Anceschi More articles by this author , Maria Carme MirMaria Carme Mir More articles by this author , Eduard RousselEduard Roussel More articles by this author , Nicola PavanNicola Pavan More articles by this author , Umberto CarbonaraUmberto Carbonara More articles by this author , Onder KaraOnder Kara More articles by this author , Tobias KlatteTobias Klatte More articles by this author , Michele MarchioniMichele Marchioni More articles by this author , Angela PecoraroAngela Pecoraro More articles by this author , Stijn MuselaersStijn Muselaers More articles by this author , Laura MarandinoLaura Marandino More articles by this author , Pietro DianaPietro Diana More articles by this author , Leonardo BorregalesLeonardo Borregales More articles by this author , Enes DegirmenciEnes Degirmenci More articles by this author , Resat AydinResat Aydin More articles by this author , Giacomo RebezGiacomo Rebez More articles by this author , Giuseppe SimoneGiuseppe Simone More articles by this author , Andrea MinerviniAndrea Minervini More articles by this author , Sergio SerniSergio Serni More articles by this author , and Faruk OzcanFaruk Ozcan More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003311.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Open and minimally invasive (MI; laparoscopic or robotic-assisted) surgical techniques are applied to treat renal cell carcinoma (RCC), and their oncological equivalence has been always questionned. This study aimed to compare prognosis and survival outcomes between open and MI techniques in patients undergoing curative surgery for non-metastatic papillary RCC (papRCC). METHODS: This multi-institutional study was conducted by the EAU-YAU Renal Cancer Working Group. A total of 2076 patients undergoing curative surgery for non-metastatic papRCC were collected for the dataset. After exclusion of 380 patients due to incomplete records or loss-to-follow-up, a total of 1696 patients were included into this study. Furthermore, a subgroup of 490 patients was defined by matching 245 patients from each operative technique at 1:1 ratio, in terms of year of surgery, age, nephrectomy type (partial/radical) and clinical tumor stage. The retrospectively collected demographical, clinical, histopathological and oncological data were compared between open and MI techniques in the overall and matched-pair cohorts. Chi-square and Mann-Whitney U tests, and Kaplan-Meier analysis were used for the statistical analyses. RESULTS: In overall, patients who underwent open surgery were more frequently male, with symptomatic disease, had a higher rate of radical nephrectomy, and presented with greater clinical and pathological T stages, tumor sizes, pathologic N1 stage, VENUSS score and risk group, and tumors with necrosis and sarcomatoid dedifferentiation. Follow-up was significantly longer in the open group, and disease free-(DFS), cancer specific-(CSS) and overall survival (OS) were significantly worse. In matched-pair comparison, symptomatic disease, pathologic N1 stage, sarcomatoid differentiation and type 2 papRCC were significantly higher in the open group. During similar follow-up duration (48 vs. 49 months, p=0.925), DFS and CSS were similar between two techniques while OS (p=0.042) was lower in the open group. CONCLUSIONS: In this multi-institutional study, open technique was associated with adverse outcomes and worse prognosis after curative surgery for non-metastatic papRCC in unbalanced overall cohort. However, although some adverse outcomes remained, there were no significant differences between the two techniques in terms of cancer-specific prognosis in a balanced matched-pair cohort. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e794 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Selcuk Erdem More articles by this author Riccardo Bertolo More articles by this author Riccardo Campi More articles by this author Umberto Capitanio More articles by this author Daniele Amparore More articles by this author Umberto Anceschi More articles by this author Maria Carme Mir More articles by this author Eduard Roussel More articles by this author Nicola Pavan More articles by this author Umberto Carbonara More articles by this author Onder Kara More articles by this author Tobias Klatte More articles by this author Michele Marchioni More articles by this author Angela Pecoraro More articles by this author Stijn Muselaers More articles by this author Laura Marandino More articles by this author Pietro Diana More articles by this author Leonardo Borregales More articles by this author Enes Degirmenci More articles by this author Resat Aydin More articles by this author Giacomo Rebez More articles by this author Giuseppe Simone More articles by this author Andrea Minervini More articles by this author Sergio Serni More articles by this author Faruk Ozcan More articles by this author Expand All Advertisement PDF downloadLoading ...