The potential role of drug transporters and amikacin modifying enzymes in M. avium.

Jodie A Schildkraut,Jordy P M Coolen,Carolien Ruesen,Jeroen J M W van den Heuvel, Laura Edo Aceña,Heiman F L Wertheim,Robert S Jansen,Jan B Koenderink,Lindsey H M Te Brake,Jakko van Ingen

Journal of global antimicrobial resistance（2023）

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摘要

We show M. avium carries ABC transporters from all major families important for antibiotic efflux, including homologues shown to have affinity for drugs included in treatment. Efflux inhibition in M. avium is able to increase susceptibility but this effect is EPI and antibiotic specific. Finally, the lack of amikacin modifying activity in M. avium is important for its activity.

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关键词

Nontuberculous mycobacteria,Mycobacterium avium,RNA sequencing,Antibiotic resistance,Tolerance

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