Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease.

Paul Anthony Martinez, Vanessa Elia Martinez,Sheela Rani,Meredith Murrell,Martin Javors,Jonathan Gelfond,Jonathan Alan Doorn,Elizabeth Fernandez,Randy Strong

Brain and behavior（2023）

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摘要

These results provide evidence to support the idea that biogenic aldehydes such as DOPAL interact with human wild-type alpha-synuclein, directly or indirectly, in vivo to exacerbate locomotor deficits in Parkinson's disease.

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关键词

aldehyde dehydrogenase, aldh1a1, aldh2, alpha-synuclein, DOPAL, oligomers

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