Synthesis of 2-Fluoroalkylated Oxazoles from -Monosubstituted Enamines via Fluoroacyloxylation and Cyclization Mediated by Fluoroalkyl-Containing Hypervalent Iodine(III) Species Generated In Situ

A metal-free synthesis of a series of fluoroalkyl-containingoxazolesfrom & beta;-monosubstituted enamines was developed. This fluoroacyloxylation/cyclizationcascade process was mediated by fluoroalkyl-containing hypervalentiodine(III) species formed in situ from the reactionof phenyliodine(III) diacetate (PIDA) and RCF2CO2H (R = H, Cl, Br, F, CF3, CH3, Ph, SAr, OAr).