Comparison of 3D and 4D robustly optimized proton treatment plans for non-small cell lung cancer patients with tumour motion amplitudes larger than 5 mm.

Physics and imaging in radiation oncology(2023)

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Abstract
All RO strategies provided acceptable plans with equally low robustness against interplay effects demanding other mitigation than rescanning to ensure fraction-wise target coverage. 4DRO considering three phases and the AvgCT provided best compromise on planning effort and robustness.
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Key words
proton treatment plans,tumour motion amplitudes,lung cancer,cell lung cancer,non-small
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