Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model

Takayuki J. Sanada,Koji Hosomi,Jonguk Park,Akira Naito,Seiichiro Sakao,Nobuhiro Tanabe,Jun Kunisawa,Koichiro Tatsumi,Takuji Suzuki

Pulmonary circulation（2023）

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摘要

This study investigated the effects of partially hydrolyzed guar gum (PHGG) on the development of pulmonary arterial hypertension using a SU5416/hypoxia rat model. Our results demonstrated that PHGG treatment suppressed the development of pulmonary hypertension and vascular remodeling with an altered gut microbiota composition.

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关键词

Akkermansia,bacteroidetes S27-7,dietary fiber,gut dysbiosis,prebiotics

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