EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion

Bruno Blanchi, Marion Taurand,Claire Colace,Sofia Thomaidou,Charlotte Audeoud,Federica Fantuzzi,Toshiaki Sawatani,Sevda Gheibi,Joan Sabadell-Basallote,Fransje W.J. Boot, Thibault Chantier, Aline Piet,Charlotte Cavanihac,Marion Pilette, Adélie Balguerie, Hamza Olleik,Françoise Carlotti,Miriam Ejarque,Malin Fex,Hindrik Mulder

Molecular Metabolism（2023）

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摘要

•EndoC-βH5, a ready to use human beta cell with excized immortalizing transgenes and extensive functional validation•Highly robust and reproducible insulin secretion in response to glucose•Unique combination of functional GIP, GLP1 and Glucagon receptor expression•CD8 T cell activation by modified HLA-A2 expressing EndoC-βH5

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关键词

Human pancreatic beta cell line,Human beta cell function,Glucose and incretin stimulated insulin secretion,Type-I diabetes disease model

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