Long Covid: Potential Role of the Reactive Species Interactome.

With interest we read the report by Behnood et al. on persistent symptoms following SARS-CoV-2 infection (aka Long COVID) in children and young people, 1 Behnood S.A. Shafran R. Bennett S.D. Zhang A.X.D. O'Mahoney L.L. Stephenson T.J. et al. Persistent symptoms following SARS-CoV-2 infection amongst children and young people: A meta-analysis of controlled and uncontrolled studies. J Infect. 2022; 84: 158-170 Abstract Full Text Full Text PDF PubMed Scopus (85) Google Scholar a group particularly vulnerable to developing life-long sequelae. Effective treatment requires interventions based on a sound understanding of the disease process, currently lacking for Long COVID. We wish to draw attention to the Reactive Species Interactome paradigm, which provides a unifying hypothesis, facilitating the design and conduct of clinical studies and enabling a structured approach to identification of novel treatments, preventing this silent pandemic from further escalating.