Identification of a novel cord blood NK cell subpopulation expressing functional programmed death receptor-1.

Marco Greppi,Valentina Obino,Rayan Goda,Federico Rebaudi,Simona Carlomagno,Mariella Della Chiesa,Simona Sivori, Gianluca Ubezio,Vanessa Agostini,Alessandra Bo,Silvia Pesce,Emanuela Marcenaro

Frontiers in immunology（2023）

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摘要

To our understanding, this study is the first to report PD-1 expression on CB derived NKs and its features in perinatal conditions. These data may prove important in selecting the most suitable CB derived NK cell population for the development of different immunotherapeutic treatments.

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关键词

programmed death receptor 1 (PD-1), human natural killer (NK) cells, cord blood (CB), killer ig-like receptor (KIR), NKG2A, NK cell maturation, immune checkpoint, human cytomegalovirus (CMV)

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