PAI-1 genetic polymorphisms influence septic patients' outcomes by regulating neutrophil activity.

Shaowei Jiang,Yang Wang,Liang Chen,Honghua Mu,Connor Meaney,Yiwen Fan,Janesh Pillay,Hairong Wang,Jincheng Zhang,Shuming Pan,Chengjin Gao

Chinese medical journal（2023）

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摘要

Genetic polymorphisms of PAI-1 can influence the serum levels of PAI-1, which might contribute to mortality by affecting neutrophil activity. Thus, patients with severe sepsis might clinically benefit from enhanced neutrophil clearance and the resolution of inflammation via the regulation of PAI-1 expression and activity.

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