A single priming event prevents oral tolerance to peanut.

Johanna M Smeekens,Robert M Immormino,Janelle R Kesselring,Andrew V Turner,Michael D Kulis,Timothy P Moran

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology（2023）

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摘要

A single airway exposure to peanut plus adjuvant is sufficient to prime the immune system to develop allergy following subsequent high-dose oral exposure. These results highlight the importance of introducing peanut as early as possible to prevent sensitization through a non-oral priming event.

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关键词

airway sensitization, CD154 T cells, food allergy, LPS, mouse model, oral tolerance, peanut allergy

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