Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product
Journal of controlled release : official journal of the Controlled Release Society(2023)
摘要
Microneedle Array Patches (MAPs) are an emerging dosage form that creates transient micron-sized disruptions in the outermost physical skin barrier, the stratum corneum, to facilitate delivery of active pharmaceutical ingredients to the underlying tissue. Numerous MAP products are proposed and there is significant clinical potential in priority areas such as vaccination. However, since their inception scientists have hypothesized about the risk of a clinically significant MAP-induced infection.
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关键词
Microneedle Array Patch (MAP),Microarray patch,Infection,Sterility,Microbiological specification,Risk assessment
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