Mp64-01 groundwater constituents and the incidence of kidney cancer

You have accessJournal of UrologyCME1 Apr 2023MP64-01 GROUNDWATER CONSTITUENTS AND THE INCIDENCE OF KIDNEY CANCER Simon John Christoph Soerensen, Maria E. Montez-Rath, Iona Cheng, Scarlett Lin Gomez, Debora L. Oh, Christian Jackson, David Rehkopf, Glenn M. Chertow, Calyani Ganesan, Alan C. Pao, John T. Leppert, and Benjamin I. Chung Simon John Christoph SoerensenSimon John Christoph Soerensen More articles by this author , Maria E. Montez-RathMaria E. Montez-Rath More articles by this author , Iona ChengIona Cheng More articles by this author , Scarlett Lin GomezScarlett Lin Gomez More articles by this author , Debora L. OhDebora L. Oh More articles by this author , Christian JacksonChristian Jackson More articles by this author , David RehkopfDavid Rehkopf More articles by this author , Glenn M. ChertowGlenn M. Chertow More articles by this author , Calyani GanesanCalyani Ganesan More articles by this author , Alan C. PaoAlan C. Pao More articles by this author , John T. LeppertJohn T. Leppert More articles by this author , and Benjamin I. ChungBenjamin I. Chung More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003322.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The incidence of kidney cancer demonstrates significant geographic variation that suggests a role for environmental risk factors, in addition to genetic and clinical risk factors. We sought to evaluate associations between groundwater environmental exposures and kidney cancer incidence. METHODS: We identified 180 constituents from 18,506 public groundwater wells in all 58 counties in California from 1996-2010. We obtained county-level kidney cancer incidence data from the California Cancer Registry from 2003-2017. Using an XWAS framework, which is the application of statistical approaches popularized in GWAS studies, we created a water-wide ecological association study (WWAS). We fit Poisson regression models to estimate the association between each constituent and county-level kidney cancer standardized incidence ratios, adjusting for known risk factors including sex, obesity, prevalence of smoking, and socioeconomic status at the county-level. RESULTS: Eleven groundwater constituents met stringent WWAS criteria and were associated with kidney cancer incidence. The seven constituents that had a positive association with kidney cancer standardized incidence ratios were chlordane (relative risk (RR)=1.06, 95% CI: 1.02–1.10), dieldrin (RR=1.04, 95% CI: 1.01–1.07), 1,2-dichloropropane (RR=1.04, 95% CI: 1.02–1.05), 2,4,5-TP (Silvex) (RR=1.03, 95% CI: 1.01–1.05), glyphosate (RR=1.02 95% CI: 1.01–1.04), endothall (RR=1.02, 95% CI: 1.01–1.03), and carbaryl (RR=1.02, 95% CI: 1.01–1.03). The constituent with the strongest inverse association was bromide (RR=0.96, 95% CI: 0.94–0.99). CONCLUSIONS: Eleven groundwater constituents met stringent WWAS criteria and were associated with kidney cancer incidence. The seven constituents that had a positive association with kidney cancer standardized incidence ratios were chlordane (relative risk (RR)=1.06, 95% CI: 1.02–1.10), dieldrin (RR=1.04, 95% CI: 1.01–1.07), 1,2-dichloropropane (RR=1.04, 95% CI: 1.02–1.05), 2,4,5-TP (Silvex) (RR=1.03, 95% CI: 1.01–1.05), glyphosate (RR=1.02 95% CI: 1.01–1.04), endothall (RR=1.02, 95% CI: 1.01–1.03), and carbaryl (RR=1.02, 95% CI: 1.01–1.03). The constituent with the strongest inverse association was bromide (RR=0.96, 95% CI: 0.94–0.99). Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e880 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Simon John Christoph Soerensen More articles by this author Maria E. Montez-Rath More articles by this author Iona Cheng More articles by this author Scarlett Lin Gomez More articles by this author Debora L. Oh More articles by this author Christian Jackson More articles by this author David Rehkopf More articles by this author Glenn M. Chertow More articles by this author Calyani Ganesan More articles by this author Alan C. Pao More articles by this author John T. Leppert More articles by this author Benjamin I. Chung More articles by this author Expand All Advertisement PDF downloadLoading ...