人脱落乳牙牙髓干细胞与牙髓干细胞生物学功能差异的效果观察
Psychological Doctor(2018)
Abstract
目的:探究人脱落乳牙牙髓干细胞与牙髓干细胞生物学功能的差异.方法:对分离培养SHED(人乳牙牙髓干细胞)和DPSCs(恒牙牙髓干细胞)进行分离培养,分别对其TNF-α、IL-6水平、Runx2、OPG、RANKL基因表达等进行检测和分析.结果:SHED的TNF-α、IL-6水平高于DPSCs(P<0.05);SHED的ALP活性与DPSCs相比更强(P<0.05);SHED的OPG、Runx2RANKL水平与DPSCs相比更高(P<0.05).结论:SHED其与DPSCs之间相比较,其不仅成骨分化能力、破骨能力均更好,表明SHED在骨改建调控中可具有一定的价值.
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