Propofol prevents oxidative stress and apoptosis by regulating iron homeostasis and targeting JAK/STAT3 signaling in SH-SY5Y cells.

Ying Zhang,Yong Zuo,Bowen Li,Jinhong Xie,Zhao Ma,Anand Thirupathi,Peng Yu,Guofen Gao,Mengtong Shi,Changhao Zhou,Hongmeng Xu,Yanzhong Chang,Zhenhua Shi

Brain Research Bulletin（2019）

引用 19|浏览15

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摘要

•Propofol prevents oxidative stress and apoptosis of nerve cells.•Propofol inhibited apoptosis via regulating iron homeostasis.•Propofol can protect against nerve injury induced by iron overload through JAK/STAT3 signaling pathway.

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关键词

AD,PRO,DMT1,Fpn1,FtH,FtL,MDA,MMP,POCD,qRT-PCR,ROS,TfR1,TUNEL,FAC,IL-6,Cox2,JAK,STAT3

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