基于高通量测序构建碘难治性分化型甲状腺癌ceRNA调控网络
World Latest Medicine Information（2022）
Abstract
目的 旨在构建竞争性内源性RNA(ceRNA)协同调控网络及鉴定碘难治性分化型甲状腺癌(radioiodine refractory-differentiated thyroid cancer，RAIR-DTC)的关键lncRNA。方法 通过高通量测序获取RAIR-DTC和碘治疗有效(NRAIR-DTC)的RNA表达谱，采用R语言的DESeq2包鉴定差异表达的lncRNA和mRNA，并根据mir-code、miRTarBase、TargetScan、miRDB数据库构建与差异表达lncRNA相关的ce
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