Wnt/β-catenin信号调节对毛囊干细胞定向分化的影响

周汝楠, 段明玥, 王一硕,罗皓文, 陈梦怡, 闫佳乐, 陈杰

Medical Aesthetics and Cosmetology（2022）

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Abstract

目的探讨Wnt/β-catenin信号调节对毛囊干细胞定向分化的影响.方法分离并培养毛囊隆突区干细胞,观察毛囊干细胞在不同时间点的生长情况.分别用10 mmol/L LiCl、10 μg/L角质形成细胞生长因子(KGF)诱导毛囊干细胞分化,采用逆转录聚合酶链反应检测干预后3、5、7、9 d后β-catenin、腺瘤性大肠息肉(APC)、糖原合成酶激酶-3β(GSK-3β)、轴蛋白(Axin)及淋巴增强因子1(LEF1)mRNA的转录水平.结果经10 mmol/L LiCl处理后,β-catenin、A

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Key words

Keratinocyte growth factor,Hair follicle stem cells,Wnt/β-catenin signaling pathway

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