广藿香及藿香油对小鼠CYP1A2、2D6的调控作用
Diet Health（2022）
Abstract
目的:研究广藿香及藿香油对主要药物代谢酶CYP1A2、CYP2D6的影响.方法:广藿香及藿香油与小鼠肝微粒体共同孵育CYP1A2底物(非那西丁)和CYP2D6底物(右美沙芬)后,用HPLC法测定上述两种底物的代谢物非那西丁和右美沙芬水平,评估广藿香及藿香油对肝药酶CYP1A2和CYP2D6的影响作用.结果:广藿香的低剂量组与藿香油的中、低剂量组小鼠肝微粒体的CYP1A2酶活性低于纯水组小鼠,且藿香油的中剂量组具有显著性差异(P＜0.05).广藿香的低剂量组与藿香油的中、低剂量组的微粒体CYP2D6酶活性低
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