Guiding DNA repair at the nuclear periphery
Nature Cell Biology（2023）
摘要
The nuclear envelope participates in the spatial regulation of DNA repair, but the mechanisms behind this are unclear. A study now reports that a nuclear envelope-localized nuclease, NUMEN/ENDOD1, guides the choice of DNA-repair pathway by inhibiting the resection of DNA ends and aberrant recombination, ensuring genome stability.
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关键词
dna repair,nuclear periphery
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