尿毒清颗粒肠道给药治疗慢性肾脏病的规范性研究
Chinese Journal of Integrated Traditional and Western Nephrology（2023）
Abstract
慢性肾脏病(chronic kidney disease,CKD)发病率逐年上升,根据一项调查示我国18岁以上成年人中CKD的患病率达10.8％[1],终末期肾脏替代治疗正以每年11％的速率上升[2],探寻治疗CKD的新疗法日益紧迫.研究发现[3],CKD患者肾脏功能受损,肠道代偿性的排泄约80％的废物及毒素;而尿毒症毒素在肠道内积累,可能会引起肠道菌群失衡,黏膜免疫紊乱[4,5].
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