Enhanced Podophyllotoxin Production of Endophyte Fusarium Proliferatum TQN5T by Host Extract and Phenylalanine.
Applied microbiology and biotechnology（2023）
Abstract
Fermentation technology using endophytes is considered a potential alternative approach for producing pharmaceutical compounds like podophyllotoxin (PTOX). In this study, fungus TQN5T (VCCM 44284) was selected from endophytic fungi isolated from Dysosma versipellis in Vietnam for PTOX production through TLC. The presence of PTOX in TQN5T was further confirmed by HPLC. Molecular identification indicated TQN5T as Fusarium proliferatum with 99.43
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Key words
Endophytes,Fermentation,Cytotoxic assay,Elicitor,Anti-cancer compounds
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