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Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease.

Anne Gulbins,Mareike Horstmann,Anke Daser,Ulrich Flögel,Michael Oeverhaus,Nikolaos E Bechrakis,J Paul Banga,Simone Keitsch,Barbara Wilker,Gerd Krause,Gary D Hammer,Andrew G Spencer,Ryan Zeidan,Anja Eckstein,Svenja Philipp,Gina-Eva Görtz

Frontiers in endocrinology（2023）

Cited 2|Views27
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Abstract
Here, we demonstrate that linsitinib effectively prevents development and progression of thyroid eye disease in an experimental murine model for Graves' disease. Linsitinib improved the total disease outcome, indicating the clinical significance of the findings and providing a path to therapeutic intervention of Graves' Disease. Our data support the use of linsitinib as a novel treatment for thyroid eye disease.
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Key words
inhibitor,disease development
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