Accumulation of plasmacytoid dendritic cell is associated with a treatment response to DNA-damaging treatment and favorable prognosis in lung adenocarcinoma.

Yoon Jin Cha,Eun Young Kim,Yong Jun Choi,Chi Young Kim,Min Kyung Park,Yoon Soo Chang

Frontiers in immunology（2023）

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摘要

There is an increased pDC in the TME of smokers' lung cancer, and the response of pDC to DNA damaging treatment would lead a conducive environment to ICIs containing regimens. These findings suggest that R&D that induces an increase in the activated pDC population is continuously required to enhance therapeutic effectiveness of ICIs-containing therapies in lung cancer.

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关键词

immune checkpoint inhibitors (ICIs), lung adenocarcinoma, plasmacytoid dendritic cells (pDCs), single cell RNA sequencing(scRNA-seq), smoking, toll-like receptor 9 (TLR9), tumor microenvironment(TME)

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